Down-regulation of Circ 0001434 accelerated inflammation in the in vitro model of ALI through miR-625-5p. Circ 0001434 expression (A), TNF-α (B), IL-1β (C), IL-6 (D), L-18 (E) levels, Gene chip (F and G), analysis f results (H), 3’UTR region of Circ 0001434 showed potential alignment with miR-625-5p sequence (I), luciferase reporter activity levels (J), miR-625-5p expression (K and L). Negative, control negative group; miRNA-376c-3p, Up-regulation of Circ 0001434 group. ##P < 0.01 versus control negative group.