Fig. 3.

Typical upstream process logging data.

Panel A shows temperature; Panel B shows control of oxygenation (i.e. DO and air flow); Panel C shows pH control (i.e. measured pH, CO₂ flow and base addition). In each case, the controlled parameter is shown in blue and plotted on the left-hand axis. For Panels B and C, actuator responses are plotted on the right-hand axes and shown in black or, in the case of base addition on Panel C, in red. Data shown is from a process run with ChAdOx1 RVF in Mobius® 3L vessels. Similar results were obtained with other viruses using Mobius® 3L vessels, and for ChAdOx2 RabG in BioBlu 3c vessels.