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. 2019 Dec 13;11(12):1156. doi: 10.3390/v11121156

Table 3.

Mean villous height, crypt depth, and villous height to crypt depth ratios in different segments at given days post inoculation (dpi).

dpi Duodenum Jejunum Ileum
Control Challenged p Control Challenged p Control Challenged p
2 Villous height (μm) 544.9 ± 15.88 447.7 ± 25.82 0.038 (*) 461.6 ± 27.97 268.1 ± 27.97 0.0001 (***) 344.9 ± 47.67 278.6 ± 47.67 0.2328 (NS)
Crypt depth (μm) 147.1 ± 8.644 180.7 ± 13.21 0.0328 (*) 147.0 ± 4.974 171.5 ± 9.240 0.0161 (*) 121.6 ± 6.506 179.5 ± 22.36 0.002 (*)
Ratio (μm/μm) 3.704 ± 1.828 2.478 ± 1.955 3.140 ± 5.623 1.563 ± 0.0003 2.836 ± 7.327 1.558 ± 1.21
4 Villous height (μm) 513.9 ± 68.77 274.1 ± 16.22 0.0003 (***) 445.4 ± 47.62 260.9 ± 14.73 0.0003 (***) 333.7 ± 11.59 264 ± 14.76 0.0001 (***)
Crypt depth (μm) 168.3 ± 5.602 190.4 ± 11.12 0.1936 (NS) 162.6 ± 7.897 161.3 ± 6.637 0.917 (NS) 122.5 ± 6.575 145.6 ± 11.06 0.0649 (NS)
Ratio (μm/μm) 3.053 ± 12.276 1.440 ± 1.459 2.739 ± 6.03 1.617 ± 2.219 2.734 ± 1.763 1.813 ± 1.335
7 Villous height (μm) 456.5 ± 32.36 420.1 ± 24.66 0.4361 (NS) 442.3 ± 29.53 451.6 ± 40.22 0.8539 (NS) 380 ± 22.29 310.2 ± 22.29 0.0728 (NS)
Crypt depth (μm) 176.7 ± 5.904 182.0 ± 14.98 0.8042 (NS) 162.6 ± 15.35 177.6 ± 11.22 0.4573 (NS) 157.3 ± 6.014 138.8 ± 11.52 0.1380 (NS)
Ratio (μm/μm) 2.583 ± 5.481 2.308 ± 1.646 2.720 ± 1.924 2.543 ± 3.585 2.416 ± 3.706 2.235 ± 1.935
10 Villous height (μm) 510.1 ± 9.831 485.4 ± 10.76 0.1181 (NS) 312.6 ± 16.88 336 ± 17.5 0.3513 (NS) 394.9 ± 8.937 367.8 ± 21.71 0.3243 (NS)
Crypt depth (μm) 188.4 ± 14.14 211.7 ± 14.12 0.5219 (NS) 194.3 ± 7.024 192.4 ± 8.213 0.8751 (NS) 158 ± 16.27 162.6 ± 8.119 0.7906 (NS)
Ratio (μm/μm) 2.571 ± 0.695 2.293 ± 0.762 1.609 ± 2.403 1.746 ± 2.131 2.429 ± 0.549 2.262 ± 2.674

* represent statistically significant. *** represent statistically very significant. NS represent difference with no significance.