Table 1.
Aim of the Study | Number of Subjects | Follow-Up Median (Years) | Main Results of the Study | 1st Author, Journal, Year |
Ref. |
---|---|---|---|---|---|
Cardiovascular Disease | |||||
Incidence of primary endpoint (a composite of CV events: Non-fatal acute myocardial infarction, non-fatal stroke or death from CV causes) |
7447 | 4.8 | Estruch et al. N. Engl. J. Med. 2018 |
[15] | |
Incidence of heart failure | 7403 | 4.8 | Papadaki et al. Eur. J. Heart. Fail. 2017 |
[20] | |
Papadaki et al. Eur. J. Heart. Fail. 2019 |
[21] | ||||
Incidence of atrial fibrillation | 6705 | 4.7 | Martínez-González et al. Circulation 2014 |
[22] | |
Cardiovascular Risk Factors | |||||
Long-term consumption of a MD could decrease the atherogenicity of LDL particles | 210 | 1.0 | Hernaez et al. Mol. Nutr. Food Res. 2017 |
[23] | |
Improvement of BP induced by a MD would be mediated by the modulation of NO bioavailability/ET-1 levels | 90 Non-smoking women with moderate hypertension |
1.0 | Storniolo et al. Eur. J. Nutr. 2017 |
[24] | |
Effects of high polyphenol consumption on BP and its relation about production of plasma NO | 200 | 1.0 | Medina-Remón et al. Nutr. Metab. Cardiovasc Dis. 2015 |
[25] | |
Effects of MD on inflammatory biomarkers related to atherosclerosis and plaque vulnerability | 164 | 1.0 | Casas et al. PLoS ONE 2014 |
[26] | |
MD effect on 24-h ambulatory BP, blood glucose, and lipids | 235 | 1.0 | Doménech et al. Hypertension 2014 |
[27] | |
Effect of the MD on heart failure biomarkers | 930 | 1.0 | Fitó et al. Eur. J. Heart Fail. 2014 |
[28] | |
Incidence of Peripheral Artery Disease (PAD) | 7435 | 4.8 | Ruiz-Canela et al. JAMA 2014 |
[29] | |
Effects of MD on BP | 7158 | 3.8 | Toledo et al. BMC medicine 2013 |
[30] | |
Effects of MD on progression of subclinical carotid atherosclerosis |
187 | 1.0 | Murie-Fernández et al. Atherosclerosis 2011 |
[31] | |
The short-term effects of MD versus those of a low-fat diet on intermediate markers of CV risk. |
772 | 0.25 | Estruch et al. Ann. Int. Med. 2006 |
[32] |
BMI: Body Mass Index; BP: Blood Pressure (mmhg); CV: Cardiovascular; MD: Mediterranean Diet; ET-1: Endothelin 1; EVOO: Extra Virgin Olive Oil; HDL: High-Density Lipoprotein; HOMA: Homeostatic Model Assessment; ICAM: Soluble İntercellular Adhesion Molecule; IL-6: İnterleukin 6; IMT: Intima-Media Thickness; LDL: Low-Density Lipoprotein; MCP-1: Monocyte Chemotactic Protein 1; NO: Nitric Oxide (Um); NT-proBNP: N-terminal pro-brain natriuretic peptide; Se-Sel: Soluble E Selectin; TNF- Α: Tumor Necrosis Factor Alpha; VCAM: Vascular Cell Adhesion Molecule; VOO: Virgin Olive Oil.