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. 2019 Dec 6;11(12):2991. doi: 10.3390/nu11122991

Table 2.

Characteristics of the RCTs conducted within the frame of the PREDIMED study, investigating the role of Mediterranean Diet (MD) on: diabetes mellitus (DM), metabolic syndrome (MetS) and obesity.

Aim of the Study Number of Subjects Follow-Up Median (Years) Main Results of the Study 1st Author,
Journal,
Year		 Ref.
Diabetes Mellitus
Effects of MD versus a low-fat diet on the need for glucose-lowering medications 3230
T2DM		 3.2 graphic file with name nutrients-11-02991-i014.jpg Basterra-Gortari et al.
Diab. Care.
2019		 [33]
Long-term effect of a MD on microvascular diabetes complications 3614
T2DM		 6.0 graphic file with name nutrients-11-02991-i015.jpg Díaz-López et al.
Diab. Care.
2015		 [34]
Díaz-López et al.
Diab. Care.
2018		 [35]
Incidence of diabetes 3541 4.1 graphic file with name nutrients-11-02991-i016.jpg Salas-Salvadó et al.
Ann Int Med.
014		 [36]
Metabolic Syndrome
Plasmatic antioxidant capabilities in Metabolic Syndrome (MetS) patients 75 5.0 graphic file with name nutrients-11-02991-i017.jpg Sureda et al.
Mol. Nutr. Food Res.
2016		 [37]
Long-term effects of MD on MetS 5801 4.8 graphic file with name nutrients-11-02991-i018.jpg Babio et al.
Cmaj
2014		 [38]
MD effects on MetS status 1224 1.0 graphic file with name nutrients-11-02991-i019.jpg Salas-Salvadó et al.
Arch. Int. Med.
2008		 [39]
Obesity
Effect of a MD on bodyweight and waist circumference 3985 4.8 graphic file with name nutrients-11-02991-i020.jpg Estruch et al.
The Lancet. Diab. Endocr.
2019		 [40]
Effect of MD on anthropometric variables and body composition parameters 305 1.0 graphic file with name nutrients-11-02991-i021.jpg Álvarez-Pérez et al.
J. Am. Coll. Nutr.
2016		 [41]
Effect of MedD on plasma total antioxidant capacity (TAC) 187 3.0 graphic file with name nutrients-11-02991-i022.jpg Razquin et al.
Eur. J. Clin. Nutr.
2009		 [42]

BMI: Body Mass Index; CI: Confidence Interval; EVOO: Extra Virgin Olive Oil; FFM: Free Fat Mass; HR: Hazard Ratio; MetS: Metabolic Syndrome; MD: Mediterranean Diet; OR: Odds Ratio; Q: Quartile; TAC: Total Antioxidant Capacity; T2DM: Type 2 Diabetes Mellitus ; TFM: Total Fat Mass; TrFM: Truncal Fat Mass; WC: Waist Circumference; %TBF: percentage of Total Body Fat.