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. 2019 Dec 5;17(12):685. doi: 10.3390/md17120685

Figure 3.

Figure 3

Protective effects of LID + TTX on aconitine-induced arrhythmia. (A) LID + TTX effects on aconitine-induced arrhythmia onset and (B) duration in live rats. (C) LID + TTX improved arrhythmic mortality in Sprague Dawley rats. Data are mean ± SD. Animals were anesthetized using 20% urethane. The doses used were as follows: Aconitine (55 μg/kg), LID (5 mg/kg), LID (5 mg/kg) + TTX (1 μg/kg), and 10 × TTX (10 μg/kg). The data from all tested animals included onset time (n = 20–25), while only data from live animals included duration. Within an observation of 120 min, 16 of 25 rats were dead in the aconitine group, 0 of 24 were dead in the LID + TTX treatment group, 8 of 20 rats were dead in the LID treatment group, and 6 of 20 rats were dead in the 10 × TTX treatment group. ** p < 0.01, *** p < 0.001 compared with the model group, as assessed using Student’s t-test; # p < 0.05, ## p < 0.01 ### p < 0.001 compared with the model group, as assessed using a χ2 test.