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. 2019 Dec 6;11(12):2997. doi: 10.3390/nu11122997

Figure 3.

Figure 3

Vitamin C upregulates the expression of synaptopodin (SYNPO2). (A) SYNPO2 RNA is increased in MDA-MB-231 cells after treatment with vitamin C for 5 days, as shown by qRT-PCR; (B,C) immunofluorescence and semi-quantification show increased SYNPO2 protein level in MDA-MB-231 cells after vitamin C treatment. Bar = 20 µm; (D,E) the level of SYNPO2 protein is higher in MDA-MB-231 xenografts from NSG mice supplemented with vitamin C (3.3 g/L) compared to mice without supplementation, as shown by immunostaining (40×) and semi-quantification.