Figure 1.

Probable Route of DENV dissemination in humans. (1) and (2) After mosquito bites, cells of the skin are infected and carry DENV to the draining lymph nodes (DLNs) via lymph. (3) From DLNs, resident macrophages (and other unknown cells) are infected and carry the virus to the lymphatic and vascular system, leading to the infection of bone marrow and spleen. (4) and (5) Later, Peyer’s patches and lymph nodes are infected and might receive DENV directly from DLNs or via bone marrow and spleen. (6) At later time points of infection, various non lymphoid organs are likely infected. However, the exact mechanism and mode of the dissemination of DENV to various organs are not precisely understood.