Table 1.
1H NMR (700 MHz) Data for PTMs 1–6 in dimethyl sulfoxide (DMSO)-d6 (δH, mult, J in Hz).
| No. | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|
| 2 | 5.70, dd, (2.3, 11.5) | 5.73, dd, (1.9, 11.4) | 5.72, dd, (2.2, 11.3) | 5.75, dd, (2.0, 11.5) | 5.75, dd, (2.1, 11.3) | 5.77, dd, (2.0, 11.5) |
| 3 | 5.90, td, (1.8, 11.2) | 5.9, td, (2.2, 11.1) | 5.92, td, (2.1, 11.0) | 5.92, td, (2.1, 11.1) | 5.96, td, (2.1, 11.1) | 5.96, td, (2.2, 11.1) |
| 4a | 1.89, m | 1.92, m | 2.00, m | 2.04, m | 2.03, m | 2.05, m |
| 4b | 3.52, m | 3.49, m | 3.62, m | 3.62, m | 3.65, m | 3.64, m |
| 5 | 1.28, m | 1.27, m | 1.90, m | 1.90, m | 1.87, m | 1.88, m |
| 6 | 1.64, m | 1.27, m | 2.09, m | 2.10, m | 2.56, m | 2.57, m |
| 7a | 0.86, m | 0.87, m | 1.05, m | 0.85, m | 0.98, m | 1.01, m |
| 7b | 1.96, m | 1.97, m | 2.05, m | 2.06, m | 2.11, m | 2.14, m |
| 8 | 2.35, m | 2.35, m | 2.35, m | 2.35, m | 2.03, m | 2.03, m |
| 9a | 0.80, m | 0.79, m | 0.84, m | 1.06, m | 0.68, m | 0.69, m |
| 9b | 2.01, m | 2.01, m | 2.05, m | 2.06, m | 2.02, m | 2.03, m |
| 10 | 1.33, m | 1.32, m | 1.37, m | 1.37, m | 1.53, m | 1.53, m |
| 11 | 1.27, m | 1.64, m | 1.09, m | 1.09, m | 1.21, m | 1.22, m |
| 12 | 1.75, m | 1.77, m | 2.21, m | 2.21, m | ||
| 13 | 1.10, m | 1.09, m | 2.37, m | 2.37, m | 2.32, m | 2.32, m |
| 14 | 3.25, m | 3.25, m | ||||
| 15a | 1.24, m | 1.24, m | 2.11, m | 2.11, m | 2.12, m | 2.13, m |
| 15b | 1.74, m | 1.75, m | 2.59, m | 2.59, m | 2.59, m | 2.60, m |
| 16 | 2.06, m | 2.07, m | 2.38, m | 2.40, m | 2.44, m | 2.47, m |
| 17 | 6.57, dd, (10.5, 15.5) | 6.55, dd, (10.5, 15.5) | 6.63, dd, (10.3, 15.6) | 6.61, t, (15.5) | 6.60, dd, (10.3, 15.5) | 6.59, dd, (11.5, 15.5) |
| 18 | 6.86, d, (15.5) | 6.95, d, (15.5) | 6.87, d, (15.6) | 6.96, d, (15.5) | 6.88, d, (15.5) | 6.96, d, (15.5) |
| 22 | NH, 8.68, s | NH, 8.68, s | NH, 8.95, s | NH, 8.73, brs | NH, 8.96, s | NH, 8.75, s |
| 23 | 3.86, d, (1.2) | 3.81, d, (5.7) | 3.87, d, (1.4) | 3.83, s | 3.87, d, (1.1) | 3.84, d, (6.1) |
| 25a | 3.81, dt, (1.5, 6.1) | 1.74, m | 3.81, dt, (1.4,6.2) | 1.74, m | 3.82, dt, (2.0, 6.4) | 1.74, m |
| 25b | 1.84, m | 1.86, m | 1.86, m | |||
| 26a | 1.18, m | 1.15, m | 1.18, m | 1.17, m | 1.20, m | 1.15, m |
| 26b | 1.38, m | 1.32, m | 1.39, m | 1.35, m | 1.39, m | 1.34, m |
| 27a | 2.57, m | 2.39, m | 2.59, m | 3.23, m | 2.58 m | 2.40, m |
| 27b | 3.25, m | 3.22, m | 3.26, m | 2.39, m | 3.24, m | 3.23, m |
| 28 | NH, 7.96, t, (5.7) | NH, 7.82, t, (5.3) | NH, 7.98, t, (5.6) | NH, 7.86, s | NH, 8.00, t, (5.6) | NH, 7.88, t, (5.6) |
| 29a | 1.04, m | 1.04, m | 1.03, m | 1.03, m | 0.99, m | 1.02, m |
| 29b | 1.55, m | 1.55, m | 1.53, m | 1.54, m | 1.51, m | 1.52, m |
| 30 | 0.85, t (7.4) | 0.85, t (7.4) | 0.84, t (7.4) | 0.84, t (7.4) | 0.84, t (7.4) | 0.84, t (7.4) |
| 31 | 1.06, d (6.4) | 1.06, d (6.4) | 0.96, d (6.5) | 0.96, d (6.5) | 0.94, d (6.7) | 0.94, d (6.8) |