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. 2019 Dec 6;16(24):4960. doi: 10.3390/ijerph16244960

Table 8.

Studies on the nervous system, and psychological and sexual aspects related to cocoa or chocolate use, included in this review.

Study Study Design Food Type Main Outcomes
Fox M. et al. 2019 [22] Randomized controlled trial human study Chocolate Dark chocolate with a high cocoa content has effects on colonic and cerebral function in healthy volunteers
Madhavadas S. et al. 2016 [94] In vivo and in vitro rat study Chocolate Dark chocolate enhanced cognitive function and cholinergic activity in the hippocampus and corrected metabolic disturbances of rats
Moreira A. et al. 2016 [97] Prospective cohort human study Chocolate Chocolate intake was associated with a lower risk of cognitive decline
Chrichton G.E. et al. 2016 [98] Longitudinal human study Chocolate Chocolate intake was associated with better cognitive function
Martin F.I. et al. 2012 [100] Randomized controlled trial in human Chocolate Snacks differing in sensory properties and presentation differently influenced postprandial anxiety, energy and emotional states
Salonia A. et al. 2006 [103] Observational human study Chocolate Positive association between daily chocolate intake and sexual function.