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. 2011 Jun 6;54(14):5116–5130. doi: 10.1021/jm2003359

Table 1. Structures of Hits from the HTS Screen.

graphic file with name jm2003359_0021.jpg

      P. falciparum strain IC50 a (nM)
  
compd EBI code R1 3D7 W2 cyotoxicity (μM)
Huh7
1a GNF-Pf-5069 Gly 63 [460] 97 [473] >10 [>100]
1b GNF-Pf-5179 (dl)-Phe 235 [119] 271 [122] >10 [>79]
1c GNF-Pf-5466 (dl)-Leu 116 [30] 119 [29] >10 [42]
a

Values are the mean of at least two experiments. Data in brackets are for resynthesized powders; otherwise data are from HTS DMSO stock solutions.