Figure 1.

Dendritic cells in the initiation of EBV and KSHV specific T cell responses and treatments of pathologies that are associated with these viruses. EBV and KSHV primarily infect B cells within the hematopoietic lineage. EBV transforms these cells into potent antigen-presenting cells that are at least involved in the expansion of virus-specific T cells but might also prime these (dashed arrow). These expanded T cells then block the outgrowth of virus-transformed B cells into lymphomas. Dendritic cells receive virus antigens either via antigen transfer from infected cells or therapeutically via antibody plus antigen hybrid molecules as well as recombinant viruses, e.g., adenovirus (rAdV), for priming and expansion of virus-specific T cells. This figure was created in part with modified Servier Medical Art templates, which are licensed under a Creative Commons Attribution 3.0 Unported License: https://smart.servier.com.