Table 4.
Apoptosis, necrosis, destabilized membranes, and cell fragments in MDA-Pca-2b control and K092B-treated cells at 4–72 h post-treatment (%).
| Cell Death | Sample | 4 h | 8 h | 12 h | 24 h | 48 h | 72 h |
|---|---|---|---|---|---|---|---|
| Apoptosis | Control | 1.7 ± 0.4 | 2.2 ± 0.2 | 2.1 ± 0.2 | 2.0 ± 0.1 | 1.6 ± 0.5 | 2.0 ± 1.0 |
| K092B | 2.2 ± 0.8 | 2.4 ± 0.4 | 3.0 ± 0.5 | 2.2 ± 0.7 | 2.3 ± 0.3 | 2.2 ± 0.7 | |
| Necrosis | Control | 5.2 ± 0.4 | 2.8 ± 1.1 | 3.9 ± 0.9 | 2.7 ± 1.2 | 2.4 ± 0.1 | 3.5 ± 1.7 |
| K092B | 5.8 ± 0.4 | 4.6 ± 0.5 * | 12.7 ± 4.1 * | 4.1 ± 0.6 | 3.8 ± 0.2 | 6.5 ± 0.8 * | |
| Destabilized membranes | Control | 7.8 ± 0.9 | 6.8 ± 0.2 | 7.0 ± 0.9 | 4.8 ± 1.1 | 3.5 ± 0.6 | 3.7 ± 0.2 |
| K092B | 8.8 ± 0.3 | 6.2 ± 0.8 | 11.5 ± 1.8 * | 6.6 ± 1.5 | 5.2 ± 1.1 | 7.6 ± 0.3 * | |
| Cell fragments | Control | 4.3 ± 0.2 | 4.5 ± 0.2 | 4.9 ± 0.4 | 3.1 ± 0.3 | 2.9 ± 0.1 | 3.4 ± 0.1 |
| K092B | 4.5 ± 1.4 | 4.3 ± 2.1 | 4.7 ± 0.4 | 3.7 ± 0.4 | 5.7 ± 0.7 * | 5.9 ± 0.7 * |
Data was obtained from three independent experiments (N = 3; n = 6) represented by mean ± SD and statistical analyses were performed while using the Mann and Whitney test (* p < 0.05, treated vs. untreated control).