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Inhibition constants (Ki) for the inhibitors ATPI-I and ATPI-II against a spectrum of serine proteases. KLK—kallikrein-related peptidase; pNA—para-nitroaniline.
| Protease | Substrate | Ki (nM) | |
|---|---|---|---|
| ATPI-I | ATPI-II | ||
| Trypsin | Ac-YASR-pNA | 0.050 ± 0.007 | 0.080 ± 0.008 |
| Chymotrypsin | Ac-GRPY-pNA | 7.4 ± 1.2 | 2.9 ± 0.3 |
| KLK5 | Ac-YASR-pNA | 1.6 ± 0.2 | 21 ± 1 |
| KLK7 | KHLY-pNA | 1.4 ± 0.1 | 3.2 ± 0.2 |
| KLK14 | Ac-YASR-pNA | 13 ± 1 | 89 ± 7 |
