Figure 2.

Liver transduction of haploid vector H-AAV8-2. (A) The composition of AAV capsid subunits. Haploid AAV viruses were produced by co-transfection of two plasmids (one encoding AAV8 VP1 and VP2, another one for AAV2 VP3). “X” represents start codon mutation. (B) Luciferase expression in the representative mice. 2 × 10¹⁰ particles of AAV vector were administered into C57BL/6. Imaging was performed at day 7. (C) The quantitation of liver transduction. The luciferase signal was measured by software. Each group contains five mice. Asterisks indicate a significant difference between the groups at the levels of ** p < 0.01.