Table 4.

List of selected open access web servers for interactive pathway visualization, metabolite mapping, and visualization in the context of pathways and metabolic networks, and metabolite set enrichment and overrepresentation analysis (MSEA, ORA).

Tool	Functionalities
MeTexplore web server [128]	Metabolite mapping on metabolic pathways and networks Visualizing networks Mining and editing networks based on data and network structure (identify sub-networks connecting identified metabolites) Pathway enrichment analysis Mapping polyomics data Computing fluxes
Pathvisio [129]	Metabolite mapping on the pathways Pathway editing, drawing, and analysis Overrepresentation analysis
iPath—Interactive Pathways Explorer [130]	Metabolite mapping on the pathways Pathway editing and analysis
MetaboAnalyst* web server [91]	Metabolite ID conversion Enrichment analysis (ORA, MSEA) Pathway topology analysis Joint pathway analysis (genes and metabolites) MS peaks to pathways
PathBank [131]	Interactive database for visualizing metabolic pathways in different model organisms Metabolite (as well as gene, protein, drug) search and mapping Detailed description and references are provided for each pathway from energy metabolism, associated with metabolic diseases, drug-action pathways, drug metabolism pathways, signaling pathways
LION/web [132]	Web platform for lipid ontology enrichment analysis Lipid classification by chemical data (LIPIDMAPS), biophysical data, lipid functions and organelle associations
XCMS online* [133]	Activity network analysis i.e., “MS peaks to metabolic network” (integrated Mummichog tool) Integrated pathway analysis (using genome and proteome data, in addition to metabolome data)

* Features relevant to pathway and network analysis have been listed here, MetaboAnalyst and XCMS online servers provide plenty of other functionalities related to data processing and analysis.