Table 1.

Intraperitoneal (i.p.) lethal dose 50 values (LD50) of botulinum neurotoxins (BoNTs) in mice.

BoNT Type.	i.p. LD50 (ng/Kg)
A1	(0.25–0.45) [23,24,25,26,27,28,29,30]
A2	(0.11–0.53) [24,26,27,31]
A3	0.85 [27,32]
A4	(400–500) [27]
A5	(0.35–0.40) [27,33]
A6	(0.26–0.3) [30,34]
B1	(0.21–0.50) [28,34,35,36,37]
B2	0.4 [38]
C1	(0.92–2.3) [39,40,41]
C/D	(0.8–1.92) [39,41]
D1	(0.02–0.83) * [28,29,39,41,42]
D/C	0.05 [41]
E1	(0.65–0.84) [24,43]
E3	3.05 [37];
F1	(2.4–3.6) # [37,44]
FA	(1.30–2.2) [38,45]
G	5.00 [46]

The toxicity values are reported as ranges between the lowest and the highest LD50 found in the literature. For each range, references that report values within the range are cited. * recombinant toxin in [28]; ^# BoNT/F in [44] is in M-PTC form; the i.p. LD50 is extrapolated from the time-to-death assay in [39,41,44].