Table 2.
Comparative toxicity of BoNTs in different animals expressed as multiple of the mouse LD50/Kg.
| BoNT Type | Source | Mouse | Rat | Guinea Pig | Rabbit | Dog | Cat | Monkey | Fowl | Pigeon | Turkey | Zebra Fish * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | [50] | 1 | 2.5 | |||||||||
| [51] | 1 | 0.5 | 0.3 | 15 | ||||||||
| [52] | 1 | 0.8 (i.m.) | ||||||||||
| [53] | 1 | 0.78 (i.m.) | ||||||||||
| [54] | 1 | 0.5 (i.v.) | ||||||||||
| [55] | 1 | 11 (inh.) | ||||||||||
| [56] | 1 | 100 (ic.) | ||||||||||
| B | [50] | 1 | 1000 | |||||||||
| [52] | 1 | 0.1 (i.m.) | ||||||||||
| [55] | 1 | 432 (inh.) | ||||||||||
| [57] | 1 | 150 (inh.) | ||||||||||
| [58] | 1 | 0.2 | ||||||||||
| [59] | 1 | 0.3 | ||||||||||
| C | [60] | 1 | 6 | 1 | 0.1 | 1.000 | 800 | 0.3 | 2000 | 20 | ||
| [61] | 1 | 7 (i.v.) | ||||||||||
| [56] | 1 | 400 (ic.) | ||||||||||
| D | [60] | 1 | 320 | 0.2 | 0.2 | 100.000 | 15.000 | 100 | 100.000 | 2000 | ||
| [56] | 1 | 20 (ic.) | ||||||||||
| E | [60] | 1 | 40 | 0.5 | 1 | 100 | 400 | 1 | 25 | 25 | ||
| F | [62] | 1 | 0.5 (s.c.) |
* IC50 immobilizing dose intracelomatic injection; i.m., intramuscular; i.v., intravenous; s.c., subcutaneous; inh., inhalation; ic., intracelomatic.