Table 3.

Oral toxicity of BoNTs of different molecular size in mice.

BoNT Type	Molecular Form of Toxin	Oral LD50 a	Relative Oral Toxicity b
A	LL-PTC	0.12 × 106	358
	L-PTC	2.2 × 106	19.5
	M-PTC	3.6 × 106	11.9
	Holotoxin	43 × 106	1
B	L-PTC	1.5 × 103	28,700
	M-PTC	1.1 × 106	39
	Holotoxin	24 × 106	1.8
C	L-PTC	5.3 × 103	8113
	M-PTC	1.6 × 105	268
D	L-PTC	6.2 × 104	693
	M-PTC	3.7 × 105	116
E	M-PTC	3.7 × 105	116
F	M-PTC	1.1 × 106	39

^a Equivalent number of i.p. LD50 (determined by the time-to-death assay). ^b The oral toxicity of type A holotoxin was taken as 1. Data for BoNT/A, /B, and/F are from [63] and for BoNT/C, /D, and /E from [44].