Table 1.

Summary information for clinical trials of therapeutic hypothermia in acute stroke patients

Name, Year	Number in hypothermia cohort (n=)	Depth of hypothermia (°C)	Time from hypothermia onset to achievement of target temperature (hrs.)	Duration at target temperature (hrs.)	Cooling method
Kammersgaard et al., 2000	17	35.5	6.00	N/A	Systemic - Surface
Kreiger et al., 2001	10	32	3.5±1.5	47.4±20.4	Systemic - Surface
De Georgia et al., 2001	18	33	1.28±0.73	24	Systemic - Infusion
Lyden et al., 2005	18	33	N/A	12-24	Systemic - Infusion
Els et al., 2006	12	35	2.00±1.00	48	Systemic - Infusion
Hemmen et al., 2010	28	33	1.11	24	Systemic - Infusion
Ovesen et al., 2013	17	33	2.11 (endovascular), 3.27 (surface)	24	Systemic - Combination
Pilronen et al., 2014	18	35	4.50	10.5	Systemic - Combination
Lyden et al., 2016	57	<35	6.00	24	Systemic - Infusion
Chen et al., 2016	26	~2 °C below baseline	0.16	N/A	Selective - Infusion
Peng et al., 2016	11	N/A	0.16	N/A	Selective - Infusion
Geurts et al., 2017	22	34.5, 35	6.87 (34.5 °C), 7.36 (35 °C)	24	Systemic - Combination
Wu et al., 2017	45	N/A	0.16	N/A	Selective - Infusion
Neugebauer et al., 2019	26	33±1	N/A	72	Systemic - Combination