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. 2019 Dec 16;17(12):707. doi: 10.3390/md17120707

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Activity of plakinamine P against multiple mycobacterial pathogens. (A,B) Cultures were treated with 16-point, 2-fold serial dilutions of plakinamine P for 2 days (fast-growing mycobacteria – panel B) and 5 days (slow-growing mycobacteria – panel A) after which the luminescence was read. The Gompertz model was used to calculate MIC (99% killing). (C) Bactericidal activity of plakinamine P against Mtb was evaluated. Cultures treated with 50, 12.5, 3.1 and 0.8 μg/mL plakinamine P were plated on 7H10 OADC and incubated for 3 weeks before colony forming unit (CFU) enumeration. The data are presented as % growth relative to average CFU/mL of the 2% DMSO controls.