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. 2019 Dec 3;11(12):705. doi: 10.3390/toxins11120705

Figure 2.

Figure 2

Effects of curine pre-treatment on in vivo cytokine production 4h after LPS challenge. Concentrations of interleukin (IL)-1β (A), IL-6 (B), tumor necrosis factor (TNF)-α (C), CCL2/monocyte chemotactic protein (MCP)-1 (D), keratinocyte-derived chemokine (KC/CXCL-1) (E) and leukotriene B4 (LTB4)(F) in the pleural lavages of C57Bl/6 mice orally pre-treated with curine (2.5 mg/kg) or dexamethasone (2 mg/kg). These results are expressed as the mean ± SD of at least 6 animals. + significant difference (p < 0.05) from the unchallenged group; * significant difference (p < 0.05) from the untreated LPS-challenged group. Statistical significance was determined with one-way ANOVA and post hoc Tukey test. Assay range of IL-1β: 10.36–60,631 pg/mL; IL-6: 0.74–12,053 pg/mL; TNF-α: 5.86–59,626 pg/mL; CCL2/MCP-1: 22.4–41,873 pg/mL; KC/CXCL1: 3.2–182 pg/mL and LTB4: 3.9–500 pg/mL.