Figure 3.

The effects of dietary calcium, dietary protein and allosteric modulators of the CaSR on histological scores of colitic mice. (a) Hematoxylin and eosin (H&E)staining of colon sections from colitic mice fed with different diets. Histological Inflammation score of colitic mice fed with different diets (b) or treated with CaSR allosteric modulators (c). Ulceration scores of colitic mice fed with different diets (d) or treated with CaSR allosteric modulators (e). Mucosal remodeling scores of colitic mice fed with different diets (f) or treated with CaSR allosteric modulators (g). Histological evaluation was carried out by an experienced pathologist under blinded conditions. Statistical significance was determined by Kruskal–Wallis test. * p < 0.05, ** p < 0.01 and *** p < 0.001 were regarded as statistically significant. Data are presented as median ± interquartile range, n = 10 and 25 mice per group, in the diets and modulators experiments, respectively.