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. 2019 Dec 16;11(12):3072. doi: 10.3390/nu11123072

Figure 6.

Figure 6

NPS-2143 reduces immune cell infiltration into the colon. (a) Representative images of colon sections stained with DAPI (blue) and cell markers for CD3 or CD20 (green) from colitic mice treated with vehicle or NPS-2143. White arrows indicate tissue infiltration, while red arrows indicate lymph node infiltration. Images were acquired with TissueFAXS and the percentage of CD3+ and CD20+ cells per tissue section was quantified using TissueQuest. CD3+ cell infiltration into tissue (b) and lymph nodes (c) in colitic mice treated with the allosteric modulators of the CaSR. CD20+ cell infiltration into tissue (d) and lymph node (e) in colitic mice treated with the allosteric modulators of the CaSR. Data are presented as the mean ± SEM. Statistical significance was determined by Kruskal–Wallis test. * p < 0.05, ** p < 0.01 and *** p < 0.001 were regarded as statistically significant. (Vehicle, n = 10), (NPS-2143, n = 11), (GSK3004774, n = 12), (cinacalcet, n = 9).