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. 2019 Dec 16;11(12):3071. doi: 10.3390/nu11123071

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pharmacokinetics for metabolites in the serum from peripherical blood from 0 to 240 min after the ingestion of the OPCO extract: 5 healthy volunteers who fasted for 12 h were given 3.2 g of a grapeseed and olive extract (OPCO) characterized for its hydroxytyrosol (HT) and procyanidins (PCy) content. The dose was set according to validated preclinical data. The OPCO extract was given under the form of 8 caps with 200 mL of water. Venous blood was collected from the cubital vein before and every 20 min after the ingestion for a total period of 240 min. Data are expressed as the mean values of 5 volunteers. Standard errors are depicted by vertical bars. The 100 min time point was chosen for enriched serum collection.