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. 2020 Jan 8;8:1. doi: 10.1186/s40364-019-0180-0

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Diagnostic potential of LOX family and ZFPM2. Using the GEO database (GSE2549), mRNA expression of known biomarker (a) or candidate genes (b) were analyzed in normal (n = 9) and MPM tissues (n = 40). Each dot represents one sample, values are mean ± SEM of each groups. Statistical analysis between normal and MPM groups was executed using unpaired Student t-test. (**** p < 0.0001, *** p < 0.001, ** p < 0.01, * p < 0.05). The In-let represents ROC curves illustrating diagnostic ability of known biomarkers (a) and candidates (b). X and Y axes stands for sensitivity as well as 1-specificity, respectively. Maximal sensitivity and specificity were determined by Youden’s method. AUC (Area Under Curve)