Fig. 4.

Long-term administration enhances the effect of anti-PD-1 antibody. The control group, the short-term group that was limited to four doses and the long-term group that continued administration until natural death or euthanasia criteria were compared (n = 5). Error bars indicate S.D. a Schema of experimental overview. b Changes in tumour volume with time until first death. The right line graph plots the mean value of tumour volume. c Evaluation of overall survival rate by Kaplan-Meier curve. P value of log rank method was 0.0002