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. 2020 Jan 8;13:9. doi: 10.1186/s13071-020-3883-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Comparative analysis of the LbrPGF2S amino acid sequence. a Multiple sequence alignment of putative PGF2S proteins from L. braziliensis (LbrM.31.2410), L. major (LmjF.31.2150), L. mexicana (LmxM.30.2150), L. infantum (LinJ.31.2210) and L. tarentolae (LtaP.31.2590). b Sequence alignment of L. braziliensis PGF2S and human putative ortholog (AKR1C3, NP_003730.4, gi|24497583) using the ClustalW algorithm. Aldo/keto reductase domains are shown in red and the blue square indicates a I247V mutation. c 3D sequence alignments of protein sequences of LmjPGF2S (PBD ID 4G5D, in grey) and human ortholog AKR1C3 (PDB ID 4YVV in blue), using RCSB PDB’s online comparison tool (rcsb.org/pdb)