Table 3.
Percent reduction of macular VD and GCC thickness in pre-perimetric and early perimetric glaucoma eyes (mean, 95% confidence interval)
| Pre-perimetric glaucoma | Early perimetric glaucoma | |||||
|---|---|---|---|---|---|---|
| VD (%) | GCC Thickness (%) | P | VD (%) | GCC Thickness (%) | P | |
| Global *, ** | 7.8 (5.0, 10.7) | 10.6 (7.5, 13.7) | 0.117 | 15.4 (10.6, 20.0) | 22.0 (17.3, 26.6) | 0.001 |
| Global SH *, ** | 6.9 (4.0, 9.8) | 9.3 (6.1, 12.5) | 0.096 | 13.3 (8.2, 18.4) | 18.4 (13.1, 23.6) | 0.004 |
| Global IH *, ** | 8.9 (5.7, 12.0) | 11.7 (8.0, 15.4) | 0.152 | 17.6 (12.7, 22.6) | 25.4 (20.1, 30.7) | 0.001 |
| Regional | ||||||
| Para *, ** | 5.1 (1.1, 9.0) | 5.9 (2.3, 9.4) | 0.338 | 11.2 (5.2, 17.3) | 19.2 (12.9, 25.6) | 0.001 |
| Peri *, ** | 7.9 (5.1, 10.7) | 12.2 (9.1, 15.3) | 0.019 | 16.1 (11.3, 20.8) | 22.9 (18.4, 27.4) | 0.001 |
| P = 0.020 | P < 0.001 | P = 0.003 | P = 0.040 | |||
| Para T *, ** | 3.5 (0.4, 6.5) | 6.0 (1.9, 10.2) | 0.128 | 12.2 (5.6, 18.9) | 20.7 (14.9, 26.6) | 0.001 |
| Para S ** | 5.2 (0.6, 9.7) | 6.7 (2.9, 10.5) | 0.234 | 9.2 (3.9, 14.6) | 17.5 (11.2, 23.7) | 0.001 |
| Para N ** | 8.2 (3.0, 13.4) | 4.0 (1.2, 7.0) | 0.873 | 11.8 (5.4, 18.2) | 17.1 (9.7, 24.6) | 0.018 |
| Para I *, ** | 3.4 (−0.01, 7.7) | 6.6 (2.5, 10.6) | 0.206 | 11.5 (4.6, 18.4) | 21.7 (13.8, 29.6) | 0.003 |
| Peri T *, ** | 7.1 (4.0, 10.3) | 12.4 (8.8, 16.0) | 0.014 | 14.2 (9.9, 18.5) | 21.8 (17.8, 25.8) | 0.001 |
| Peri S *, ** | 8.4 (5.4, 11.5) | 12.8 (9.0, 16.7) | 0.026 | 15.1 (9.6, 20.7) | 21.5 (15.4, 27.6) | 0.005 |
| Peri N *, ** | 5.0 (2.5, 7.5) | 8.1 (5.2, 11.1) | 0.103 | 13.6 (7.8, 19.3) | 18.3 (13.0, 23.6) | 0.013 |
| Peri I *, ** | 11.0 (7.5, 14.5) | 16.5 (11.8, 21.5) | 0.023 | 21.3 (16.3, 26.3) | 31.0 (25.3, 36.7) | 0.001 |
A clustered Wilcoxon signed rank test using the Rosner-Glynn-Lee method was used to compare the percent reduction of macular VD or GCC thickness between different areas within each individual group
P, P values between macular VD and GCC thickness or between the different regions in the individual group
VD Vessel density, GCC Ganglion cell complex, SH Superior hemifield, IH Inferior hemifield, para Parafoveal, peri Perifoveal, T Temporal, S superior, N Nasal, I Inferior
Multivariate analysis using a mixed effects model that was adjusted for age, sex, and SSI was used for the comparison between the PPG and early PG groups in terms of the percent reduction of VD (*, P < 0.05) and GCC thickness (**, P < 0.05)