Table 1.
List of 37 enriched genes belonging to the DNA binding category (GO:0003677)
| Group | Gene name | CGI position (hg19) | State | # DMP | DEG |
|---|---|---|---|---|---|
| HOX proteins | HOXD4 | chr2:177014948-177015214 | Hyper | 2 | |
| HOXD3 | chr2:177029413-177029941 | Hyper | 1 | Up | |
| MEIS1 | chr2:66672431-66673636 | Hypo | 3 | ||
| HOXA3 | chr7:27163819-27164098 | Hyper | 3 | Up | |
| HOXB3 | chr17:46631800-46632212 | Hyper | 1 | Up | |
| HIST1 proteins | HIST1H3A | chr6:26020671-26021125 | Hyper | 1 | |
| HIST1H4A | chr6:26020671-26021125 | Hyper | 3 | ||
| HIST1H2BK | chr6:27107138-27107394 | Hyper | 1 | ||
| HIST1H2AL | chr6:27833120-27833406 | Hyper | 4 | ||
| HIST1H1B | chr6:27835190-27835461 | Hyper | 1 | ||
| ZNF transcription factors | PRDM16 | chr1:3102540-3103352 | Hypo | 2 | |
| ZNF512 | chr2:27805754-27806078 | Hyper | 1 | Down | |
| ZNF518B | chr4:10458129-10459353 | Hyper | 1 | Down | |
| CXXC5 | chr5:139040819-139041028 | Hypo | 1 | Up | |
| FEZF1 | chr7:121943867-121944538 | Hypo | 3 | ||
| TRPS1 | chr8:116660432-116660747 | Hyper | 1 | ||
| ZNF263 | chr16:3332472-3333847 | Hypo | 1 | ||
| ZNF397OS | chr18:32847284-32848130 | Hyper | 1 | ||
| ZNF441 | chr19:11877720-11878280 | Hypo | 1 | Up | |
| ZNF69 | chr19:11998804-11999131 | Hypo | 10 | Up | |
| ZNF700 | chr19:12035899-12036433 | Hypo | 9 | Up | |
| ZNF763 | chr19:12076029-12076366 | Hypo | 9 | ||
| ZNF529 | chr19:37095680-37096589 | Hyper | 1 | ||
| Transcription factors | SP5 | chr2:171569877-171573904 | Hypo | 2 | |
| SP3 | chr2:174828330-174830617 | Hypo | 1 | ||
| NEUROD6 | chr7:31375845-31376542 | Hyper | 1 | ||
| PAX5 | chr9:36985986-36986924 | Hypo | 1 | Up | |
| CREBZF | chr11:85374872-85376234 | Hypo | 1 | ||
| SIM2 | chr21:38079941-38081833 | Hypo | 1 | ||
| DNA-binding proteins | COLEC11 | chr2:3683029-3683290 | Hypo | 1 | |
| WRNIP1 | chr6:2765203-2766775 | Hyper | 2 | ||
| JRK | chr8:143750759-143751448 | Hypo | 2 | ||
| FBXO21 | chr12:117627650-117628488 | Hypo | 2 | Up | |
| KDM2B | chr12:121975028-121976140 | Hyper | 1 | ||
| POLE | chr12:133249979-133250243 | Hypo | 1 | Down | |
| WNT1 | chr12:49371690-49375550 | Hyper | 2 | ||
| SMC1B | chr22:45809191-45809953 | Hypo | 2 |
Genes annotated to a CGI+ with at least 1 DMP. Columns denote groups of encoded proteins, position of CGIs, methylation state, number of DMPs and differential expression of genes (DEG; Up upregulated, Down downregulated; p < 0.05)