Table 3.
Crude and adjusted hazard ratios (HR) of 5-year mortality from time since IPF diagnosis, for the significant baseline predictors at diagnosis, with redefined cut-points for age and TLCO categories defining the GAP indexb, estimated by Cox proportional hazards model
| n (%) | Crude HR | Adjusted HRa (95% CI) | |
|---|---|---|---|
| Age at diagnosis | |||
| ≥ 75 years | 353 (22) | 1.54 | 2.16 (1.61–2.89) |
| 65–74 years | 730 (45) | 1.16 | 1.34 (1.04–1.74) |
| < 65 years | 537 (33) | Reference | Reference |
| Men | 1157 (71) | 1.76 | 1.52 (1.16–1.97) |
| Predicted FVC | |||
| < 50% | 78 (5) | 5.62 | 3.80 (2.53–5.70) |
| 50–75% | 669 (41) | 2.66 | 1.98 (1.55–2.54) |
| > 75% | 873 (54) | Reference | Reference |
| Predicted TLCO | |||
| ≤ 55% | 1106 (68) | 4.63 | 3.22 (2.27–4.56) |
| > 55% | 514 (32) | Reference | Reference |
aAdjusted for all other predictors, concordance-index = 0.75
b Scores based on magnitude of hazard ratios