Table 4.
Crude and adjusted hazard ratios (HR) of 5-year mortality from time since IPF diagnosis for the original GAP stages and with redefined cut-points, as estimated by the Cox proportional hazards model
| Number (%) | Crude HR (95% CI) | Adjusted HRa (95% CI) | |
|---|---|---|---|
| GAP stage | |||
| I | 772 (47.7) | Reference | Reference |
| II | 710 (43.8) | 3.32 (2.59–4.26) | 2.89 (2.25–3.73) |
| III | 138 (8.5) | 5.12 (3.60–7.28) | 3.97 (2.76–5.71) |
| GAP stage with redefined cut-points | |||
| I | 488 (30.1) | Reference | Reference |
| II | 485 (29.9) | 3.22 (1.97–4.31) | 2.66 (1.80–3.94) |
| III | 647 (39.9) | 6.92 (4.86–9.85) | 5.79 (4.03–8.31) |
aAdjusted for pulmonary hypertension, lung cancer and long-term oxygen therapy, concordance index = 0.81 and 0.77 respectively