Table 3.

Innate immune genes defined as suppressors or enhancers of neurodegeneration

Reference	Gene symbol	Gene effect	Protein function	Signaling vs. effectors
Ambegaokar and Jackson[65], 2011	mei-9	Suppressor	Protein binding	Unknown
Ambegaokar and Jackson [65], 2011	Meek1	Enhancer	Kinase	Signaling
Ambegaokar and Jackson [65], 2011	Nrg	Suppressor	Calcium ion binding	Effector
Ambegaokar and Jackson [65], 2011	RpS21	Enhancer	Ribosome binding	Unknown
Blard et al. [62], 2007	Myd88	Enhancer	Protein binding	Signaling
Blard et al. [62], 2007	E(bx)	Enhancer	DNA binding	Unknown
Blard et al. [62], 2007	Sodh-1	Enhancer	Enzyme	Unknown
Chan et al. [66], 2002; Zhang et al. [59], 2010	Uba2	Enhancer	SUMO activating enzyme	Signaling
Kaltenbach et al. [63], 2007	Eip75B	Suppressor	DNA binding	Signaling
Shulman and Feany [60], 2003	par-1	Suppressor	Protein kinase	Unknown
Zhang et al. [59], 2010	Hop	Suppressor	Protein binding	Signaling
Zhang et al. [59], 2010	brm	Enhancer	Protein binding	Signaling
Zhang et al. [59], 2010	lwr	Enhancer	Protein binding, SUMO ligase	Signaling
Zhang et al. [59], 2010	Rab11	Enhancer	Protein binding, GTPase	Signaling
Zhang et al. [59], 2010	Jra	Suppressor	Protein binding, DNA binding	Signaling
Zhang et al. [59], 2010	lic	Enhancer	Protein kinase	Signaling
Zhang et al. [59], 2010	Slu7	Enhancer	Zinc anion binding, nucleic acid binding	Unknown