Table 2.
Association of PWI With Incident Dementia, Atherosclerosis Risk in Communities Study, 1990–2015
| PTFV1 | No aPTFV1 (n=11 063) | aPTFV1 (n=2651) | P Value |
|---|---|---|---|
| # Dementia events | 1066 | 324 | |
| Person‐years | 202 973 | 38 486 | |
| Incidence rate (95% CI)a | 5.3 (4.9–5.6) | 8.4 (7.5–9.4) | |
| Hazard ratio (95% CI) | |||
| Model 1 | 1 (REF) | 1.70 (1.50–1.93) | <0.0001 |
| Model 2 | 1 (REF) | 1.65 (1.45–1.87) | <0.0001 |
| Model 3 | 1 (REF) | 1.60 (1.41–2.83) | <0.0001 |
| PPWD | No PPWD (n=9865) | PPWD (n=3849) | P Value |
|---|---|---|---|
| No. dementia events | 934 | 456 | |
| Person‐years | 179 657 | 60 972 | |
| Incidence rate (95% CI)a | 5.2 (4.9–5.5) | 7.5 (6.8–8.2) | |
| Hazard ratio (95% CI) | |||
| Model 1 | 1 (REF) | 1.66 (1.48–1.86) | <0.0001 |
| Model 2 | 1 (REF) | 1.64 (1.46–1.84) | <0.0001 |
| Model 3 | 1 (REF) | 1.60 (1.42–1.80) | <0.0001 |
| PWA | No aPWA (n=11 589) | aPWA (n=2125) | P Value |
|---|---|---|---|
| No. dementia events | 1164 | 226 | |
| Person‐years | 210 701 | 32 497 | |
| Incidence rate (95% CI)a | 5.5 (5.2–5.8) | 7.0 (6.1–7.9) | |
| Hazard ratio (95% CI) | |||
| Model 1 | 1 (REF) | 1.49 (1.29–1.72) | <0.0001 |
| Model 2 | 1 (REF) | 1.40 (1.21–1.62) | <0.0001 |
| Model 3 | 1 (REF) | 1.36 (1.17–2.57) | <0.0001 |
| aIAB | No aIAB (n=13 456) | aIAB (n=258) | P Value |
|---|---|---|---|
| No. dementia events | 1368 | 22 | |
| Person‐years | 243 984 | 3425 | |
| Incidence rate (95% CI)a | 5.6 (5.3–5.9) | 6.4 (4.1–9.5) | |
| Hazard ratio (95% CI) | |||
| Model 1 | 1 (REF) | 1.01 (0.66–1.55) | 0.95 |
| Model 2 | 1 (REF) | 0.98 (0.64–1.50) | 0.94 |
| Model 3 | 1 (REF) | 0.93 (0.61–1.42) | 0.72 |
Model 1 is adjusted for age, sex and race/field center. Model 2: Model 1 and additionally adjusted for education, occupation, apolipoprotein E, smoking, body mass index, systolic blood pressure, diastolic blood pressure, antihypertensive medication, total cholesterol, diabetes mellitus, prevalent coronary heart disease, heart failure, and stroke. Model 3: Model 2 and additionally adjusted for time‐dependent incident stroke and AF. All covariates except sex, race‐field center, education, occupation, and apolipoprotein E are time‐varying variables. aIAB indicates advanced interatrial block; aPWA, abnormal P‐wave axis; PPWD, prolonged P‐wave duration; PTFV1, the terminal force of the P wave in ECG lead V1.
Incidence rate is per 1000 person‐years.