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. 2019 Dec 14;8(24):e014451. doi: 10.1161/JAHA.119.014451

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Chronic stress and siRNA treatment (n=8/group) interacted leading to altered circadian mean arterial pressure (A). Analysis of cumulative arterial pressure indicated that CVS, only in siRNA‐treated rats, increased chronic mean arterial pressure (B), systolic arterial pressure (C), and diastolic arterial pressure (D). *P<0.05 CVS siRNA vs No CVS siRNA, **P<0.01 CVS siRNA vs No CVS siRNA, ^† P<0.05 CVS siRNA vs CVS GFP, ^†††† P<0.0001 CVS siRNA vs CVS GFP, ^‡P<0.05 No CVS siRNA vs No CVS GFP, ^§ P<0.05 CVS siRNA vs No CVS GFP. AUC indicates area under the curve; CVS, chronic variable stress; D, dark cycle; GFP, green fluorescent protein; L, light cycle; siRNA, small interfering RNA.