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. 2019 Dec 14;8(24):e014451. doi: 10.1161/JAHA.119.014451

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Chronic stress as well as CVS siRNA increased circadian pulse pressure (A). Cumulative pulse pressure was increased in CVS exposed rats, with CVS siRNA rats experiencing the greatest chronic pulse pressure (B). *P<0.05 CVS GFP vs No CVS GFP, ^† P<0.05 CVS siRNA vs No CVS GFP, ^†††† P<0.0001 CVS siRNA vs No CVS GFP, ^‡ P<0.05 CVS siRNA vs No CVS siRNA, ^‡‡‡‡ P<0.0001 CVS siRNA vs No CVS siRNA, ^§ P<0.05 CVS siRNA vs CVS GFP. AUC indicates area under the curve; CVS, chronic variable stress; D, dark cycle; GFP, green fluorescent protein; L, light cycle; siRNA, small interfering RNA.