. 2019 Dec 14;8(24):e014451. doi: 10.1161/JAHA.119.014451

Table 3.

siRNA and/or CVS Effects From Experiments 1 and 2

	siRNA	CVS	siRNA+CVS
Activity (15 day total counts)	↔	↓ ^*	↑ ^* ^, ^† ^, ^‡
HR (15 d)	↓ ^*	↓ ^*	↑ ^† ^, ^‡
MAP (15‐d AUC)	↓ ^*	↔	↑ ^* ^, ^† ^, ^‡
SAP (15‐d AUC)	↓ ^*	↔	↑ ^* ^, ^† ^, ^‡
DAP (15‐d AUC)	↓ ^*	↔	↑ ^* ^, ^†
Pulse pressure (15‐d AUC)	↔	↑ ^*	↑ ^* ^, ^† ^, ^‡
HR (acute stress)	↑ ^*	↑ ^*	↑ ^* ^, ^† ^, ^‡
MAP (acute stress)	↑ ^*	↑ ^*	↑ ^* ^, ^†
Vasoconstriction (ED)	↔	↔	↓ ^* ^, ^† ^, ^‡
Vasoconstriction (EI)	↓ ^*	↓ ^*	↓ ^* ^, ^† ^, ^‡
Vasorelaxation (ED)	↔	↔	↓ ^* ^, ^† ^, ^‡
Vasorelaxation (EI)	↔	↓ ^*	↓ ^* ^, ^†
Lumen circumference	↔	↔	↓ ^†
Luminal area	↔	↔	↓ ^†
Media Thickness	↔	↑ ^*	↑ ^* ^, ^†
Media:lumen area	↔	↑ ^*	↑ ^* ^, ^†
Adventitia thickness	↔	↔	↓ ^*
Adventitia collagen	↔	↑ ^*	↑ ^* ^, ^†
Heart weight	↔	↑ ^*	↑ ^* ^, ^†
Heart weight/body weight	↔	↔	↑ ^*
Myocardial collagen	↔	↔	↔
Myocyte surface area	↔	↑ ^*	↑ ^* ^, ^†

Integrative summary of all data reported in terms of small interfering RNA effects, chronic stress effects, and the combination of small interfering RNA and chronic variable stress. Arrows indicate significant small interfering RNA and/or chronic variable stress effects. AUC indicates area under the curve; CVS, chronic variable stress; DAP, diastolic arterial pressure; ED, endothelial‐dependent; EI, endothelial‐independent; HR, heart rate; MAP, mean arterial pressure; SAP, systolic arterial pressure; siRNA, small interfering RNA.

*P<0.05 vs No CVS GFP, ^† P<0.05 vs No CVS siRNA, ^‡ P<0.05 vs CVS GFP.