Table 1.
US MEDPED Criteria for FH Diagnosis22
| FH Is Diagnosed if Total Cholesterol Exceeds These Cut‐Off Points in mg/dL (mmol/L)a | ||||
|---|---|---|---|---|
| Age, y | First‐Degree Relative With FH | Second‐Degree Relative With FH | Third‐Degree Relative With FH | General Population |
| <20 | 220 mg/dL (5.7 mmol/L) | 230 mg/dL (5.9 mmol/L) | 240 mg/dL (6.2 mmol/L) | 270 mg/dL (7.0 mmol/L) |
| 20–29 | 240 mg/dL (6.2 mmol/L) | 250 mg/dL (6.5 mmol/L) | 260 mg/dL (6.7 mmol/L) | 290 mg/dL (7.5 mmol/L) |
| 30–39 | 270 mg/dL (7.0 mmol/L) | 280 mg/dL (7.2 mmol/L) | 290 mg/dL (7.5 mmol/L) | 340 mg/dL (8.8 mmol/L) |
| ≥40 | 290 mg/dL (7.5 mmol/L) | 300 mg/dL (7.8 mmol/L) | 310 mg/dL (8.0 mmol/L) | 360 mg/dL (9.3 mmol/L) |
FH indicates familial hypercholesterolemia; MEDPED, Make Early Diagnosis to Prevent Early Death.
a
The total cholesterol cut‐off points for FH are dependent upon the confirmed cases of FH in the family. If FH is not diagnosed in the family, then the cut‐off point for diagnosis is as per “general population.”