Table 2.

Simon Broome Criteria for the Diagnosis of FH (UK FH Registers Criteria)23

Criteria	Possibility
In adults: TC >7.5 mmol/L (290.0 mg/dL) (or when available, LDL‐C >4.9 mmol/L [189.5 mg.dL]) In pediatric patients: TC >6.7 mmol/L (259.1 mg/dL), or LDL‐C >4 mmol/L (154.7 mg/dL), AND	Definite
Tendon xanthoma in the patient or first/second‐degree relative, OR alternatively:
Presence of LDL‐R, ApoB, or PCSK9 mutation
In adults: TC >7.5 mmol/L (290.0 mg/dL) (or when available, LDL‐C >4.9 mmol/L [189.5 mg.dL]) In pediatric patients: TC >6.7 mmol/L (259.1 mg/dL), or LDL‐C >4 mmol/L (154.7 mg/dL), AND	Possible
Family history of MI <50 y old in second‐degree relative or <60 y old in first‐degree relative OR alternatively
Family history of TC >7.5 mmol/L (290.0 mg/dL) in a first‐ or second‐degree relative.

To convert LDL‐C in mmol/L to mg/dL, multiply by 38.67. ApoB indicates apolipoprotein B; FH, familial hypercholesterolemia; LDL, low‐density lipoprotein; LDL‐R, low‐density lipoprotein receptor; MI, myocardial infarction; PCSK9, proprotein convertase subtilisin/kexin type 9; TC, total cholesterol.