Table 3.
Dutch Lipid Network Criteria for Diagnosis of FH24
| Criteria | Score |
|---|---|
| Family history | |
| Premature CVD (men <55 y old, women <60 y old) in first‐degree relative, OR | 1 |
| LDL >95th percentile in first‐degree relative AND/OR | 1 |
| Tendon xanthoma and/or arcus cornealis in first‐degree relative, OR | 2 |
| LDL >95th percentile in children <18 y old | 2 |
| Personal history | |
| Premature CAD in patient (men <55 y old, women <60 y old) | 2 |
| Premature cerebral or peripheral vascular disease (men <55 y old, women <60 y old) | 1 |
| Clinical examination | |
| Tendon xanthomas, OR | 6 |
| Corneal arcus younger than 45 y old | 4 |
| LDL | |
| >330 mg/dL (8.5 mmol/L) | 8 |
| 250–329 mg/dL (6.5–8.5 mmol/L) | 5 |
| 190–249 mg/dL (4.9–6.4 mmol/L) | 3 |
| 155–189 mg/dL (4.0–4.9 mmol/L) | 1 |
| Presence of functional LDL‐R mutation (in the LDL‐R, ApoB, or PCSK9 gene) | 8 |
| Diagnosis based on the overall score | |
| Definite | >8 |
| Probable | 6–8 |
| Possible | 3–5 |
| Unlikely | <3 |
ApoB indicates apolipoprotein B; CAD, coronary artery disease; CVD, cardiovascular disease; FH, familial hypercholesterolemia; LDL, low‐density lipoprotein; LDL‐R, low‐density lipoprotein receptor; PCSK9, proprotein convertase subtilisin/kexin type 9.