Table 3.
Multivariate Analysis of Factors Associated With Low‐Dose Aspirin Use for Primary Prevention of CVD in the SCCS
| Variable | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P Valuea | OR (95% CI) | P Valuea | OR (95% CI) | P Valuea | |
| Race/ethnicity | ||||||
| White | Ref. | Ref. | Ref. | |||
| Black | 0.61 (0.59–0.64) | <0.001 | 0.73 (0.70–0.76) | <0.001 | 0.79 (0.75–0.82) | <0.001 |
| Year of SCCS enrollment | ||||||
| 2002–2003 | … | … | Ref. | Ref. | ||
| 2004–2005 | … | … | 1.57 (1.48–1.66) | <0.001 | 1.41 (1.33–1.50) | <0.001 |
| 2006–2007 | … | … | 1.87 (1.75–1.99) | <0.001 | 1.77 (1.66–1.89) | <0.001 |
| 2008–2009 | … | … | 1.65 (1.54–1.78) | <0.001 | 1.61 (1.49–1.74) | <0.001 |
| Age, y | ||||||
| 40–49 | … | … | Ref. | Ref. | ||
| 50–59 | … | … | 1.79 (1.70–1.89) | <0.001 | 1.77 (1.67–1.87) | <0.001 |
| 60–69 | … | … | 2.82 (2.64–3.00) | <0.001 | 2.87 (2.69–3.06) | <0.001 |
| 70–79 | … | … | 3.52 (3.21–3.87) | <0.001 | 3.97 (3.60–4.37) | <0.001 |
| Sex | ||||||
| Female | … | … | Ref. | Ref. | ||
| Male | … | … | 0.65 (0.62–0.68) | <0.001 | 0.74 (0.70–0.77) | <0.001 |
| 10‐y CVD risk | ||||||
| Low risk | … | … | Ref. | Ref. | ||
| Intermediate risk | … | … | 1.46 (1.32–1.62) | <0.001 | 1.46 (1.31–1.61) | <0.001 |
| High risk | … | … | 2.49 (2.27–2.73) | <0.001 | 1.96 (1.78–2.16) | <0.001 |
| Diabetes mellitus | ||||||
| No | … | … | … | … | Ref. | |
| Yes | … | … | … | … | 2.45 (2.33–2.58) | <0.001 |
| History of ulcer | ||||||
| No | … | … | … | … | Ref. | |
| Yes | … | … | … | … | 1.06 (1.00–1.14) | 0.060 |
| Concomitant NSAIDs | ||||||
| No | … | … | … | … | Ref. | |
| Yes | … | … | … | … | 1.53 (1.45–1.61) | <0.001 |
| Annual household income | ||||||
| <$15 000 | … | … | … | … | Ref. | |
| $15 000 to <$25 000 | … | … | … | … | 1.18 (1.11–1.25) | <0.001 |
| $25 000 to <$50 000 | … | … | … | … | 1.41 (1.32–1.51) | <0.001 |
| ≥$50 000 | … | … | … | … | 1.85 (1.72–2.00) | <0.001 |
| Education | ||||||
| Less than high school | … | … | … | … | Ref. | |
| High school completed | … | … | … | … | 1.13 (1.07–1.20) | <0.001 |
| Higher than high school | … | … | … | … | 1.25 (1.18–1.33) | <0.001 |
Model 1 includes race/ethnicity. Model 2 includes model 1 plus year of SCCS enrollment, age at enrollment, sex, and Framingham 10‐year CVD risk category. Model 3 includes model 2 plus diabetes mellitus status, history of ulcer, concomitant use of NSAIDs, annual household income, and education level. CVD indicates cardiovascular disease; OR, odds ratio; Ref., referent; SCCS, Southern Community Cohort Study.
a
P value from Wald test compared with ref.