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. 2019 Dec 16;8(24):e014986. doi: 10.1161/JAHA.119.014986

Table 4.

COMT rs4818 and rs4680 Gene‐Dosage (Per Allelea) Association With Rates of CVD in MESA

SNP Race/Ethnicity Events/No. HR (95% CI), P Value
rs4818 All, model 1b 498/5984 0.85 (0.74–0.97), 0.02
All, model 2c 497/5961 0.85 (0.74–0.98), 0.02
White 203/2332 0.90 (0.74–1.09), 0.29
Black 122/1518 0.85 (0.62–1.16), 0.32
Hispanic 130/1375 0.71 (0.53–0.95), 0.02
Asian 43/759 0.90 (0.74–1.09), 0.29
rs4680 All, model 1b 524/6157 0.95 (0.84–1.08), 0.46
All, model 2c 495/6066 0.96 (0.85–1.09), 0.56
White 214/2476 1.02 (0.84–1.23), 0.86
Black 130/1575 0.97 (0.75–1.25). 0.79
Hispanic 137/1426 0.94 (0.73–1.19), 0.59
Asian 43/768 0.68 (0.43–1.07), 0.10
a

Allele key: rs4818 coded allele=G, reference=C; rs4680 coded allele=Val (G), reference=Met (A).

b

Model 1: meta‐analysis of Cox proportional models adjusted for age, sex, race, site, and the first 5 principal components specific to each of the 4 race/ethnicities.

c

Model 2: meta‐analysis of Cox proportional models adjusted for time‐varying cardiovascular disease (CVD) risk factors from examination 1 to 5: body mass index, triglycerides, high‐density lipoprotein, low‐density lipoprotein, cholesterol, systolic blood pressure and history of smoking, diabetes mellitus, and hypertension in addition to age, sex, race, and the first 5 principal components specific to each of the 4 race/ethnicities. COMT indicates catechol‐O‐methyltransferase; HR, hazard ratio; MESA, Multi‐Ethnic Study of Atherosclerosis; SNP, single nucleotide polymorphism.