Table 5.
COMT rs4818 and rs4680 Gene‐Dosage (Per Allelea) Association With Rates of CVD Stratified by Aspirin Use Overall and by Race
| Race/Ethnicity | Aspirin <3 d/wk | Aspirin ≥3 d/wk | P interaction | ||
|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | ||
| Overallb | 0.79 (0.65–0.95) | 0.02 | 0.89 (0.71–1.13) | 0.34 | 0.39 |
| White | 0.83 (0.61–1.11) | 0.21 | 0.90 (0.66–1.22) | 0.34 | 0.70 |
| Black | 0.65 (0.40–1.04) | 0.07 | 1.27 (0.77–2.11) | 0.38 | 0.06 |
| Hispanic | 0.70 (0.48–1.02) | 0.06 | 0.65 (0.39–1.08) | 0.10 | 0.81 |
| Asian | 1.09 (0.63–1.89) | 0. 76 | 0.19 (0.01–2.40) | 0.20 | 0.21 |
COMT indicates catechol‐O‐methyltransferase; CVD, cardiovascular disease; HR, hazard ratio.
a
Allele key: rs4818 coded allele=G, reference=C.
b
Meta‐analysis of Cox proportional models adjusted for age, sex, race, site, and the first 5 principal components specific to each of the 4 race/ethnicities.