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. 2019 Dec 30;25:10164–10172. doi: 10.12659/MSM.919112

Figure 3.

Figure 3

DMED upregulates miR-155 to mediate cell proliferation, apoptosis, migration, and invasion of OC cells. (A) qRT-PCR was performed to detect miR-155 expression in SKOV3 cells; (B) CCK-8 assay was used to measure SKOV3 cell proliferation; (C) Cell apoptosis rate was observed under the application of flow cytometry. The expression of caspase-3 and Mcl-1 were determined by (D) qRT-PCR and (E) Western blot. Wound healing assay and Transwell were used to detect (F) cell migration and (G) Invasion ability. * P<0.05, ** P<0.01, *** P<0.001, compared with Blank group; # P<0.05, ## P<0.01, compared with DMED group; DMED – Dexmedetomidine.