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. 2020 Jan 6;8:e8318. doi: 10.7717/peerj.8318

Figure 6. Functional annotation of hub miRNAs in each module ((A and B) blue module; (C and D) brown module; (E and F) turquoise module; (G and H) yellow module): enriched KEGG pathways (A, C, E, G) and REACTOME pathways (B, D, F, H).

Figure 6

The y-axis represents the metabolic pathway in which the target genes of the hub miRNAs are involved, and the x-axis represents the ratio of Hits value of the mRNA enriched in each metabolic pathway to all mRNAs in this metabolic pathway. The size of the circle represents the Hits value of the target gene of the microRNA, and the color of the circle represents the significance of the signal pathway in which the target gene is involved (–log10(p)), and the redder color indicates a significantly higher value. The hub miRNAs in each module were shown in Table 1.