Table 3. Clinical outcomes in double embryo transfer, stratified by age and prognosis.
| Favorable prognosis | Average prognosis | Poor prognosis | P-valuea | |
|---|---|---|---|---|
| 35–37 years | ||||
| No. of cycles | 487 | 483 | 164 | |
| No. of pregnancies | 240 | 198 | 59 | |
| Clinical pregnancy rateb,d | 49.3%e | 41.0%e | 36.0%e | 0.003 |
| Implantation rateb,d | 310/974 (31.8) | 249/966 (25.8) | 68/328 (20.7) | <0.001 |
| No. of twin pregnancies | 70 | 51 | 9 | |
| Twin pregnancy rate | 29.2% | 25.8% | 15.3% | 0.092 |
| Live birth rateb,d | 217 (44.6)g,i | 185 (38.3)g | 51 (31.1)g | 0.006 |
| 38–40 years | ||||
| No. of cycles | 221 | 262 | 98 | |
| No. of pregnancies | 97 | 100 | 29 | |
| Clinical pregnancy rate | 43.9% | 38.2% | 29.6%f | 0.051 |
| Implantation ratec,d | 123/442 (27.8) | 122/524 (23.3) | 32/196 (16.3) | 0.007 |
| No. of twin pregnancies | 26 | 22 | 3 | |
| Twin pregnancy rate | 26.8% | 22.0% | 10.3% | 0.173 |
| Live birth rated | 86 (38.9) | 91 (34.7) | 24 (24.5)h | 0.044 |
| >40 years | ||||
| No. of cycles | 104 | 161 | 58 | |
| No. of pregnancies | 37 | 48 | 8 | |
| Clinical pregnancy ratec,d | 35.6% | 29.8% | 13.8% | 0.012 |
| Implantation ratec,d | 43/208 (20.7) | 53/322 (16.5) | 8/116 (6.9) | 0.039 |
| No. of twin pregnancies | 6 | 5 | 0 | |
| Twin pregnancy rate | 16.2% | 10.4% | 0% | 0.553 |
| Live birth ratec,d | 32 (30.8) | 42 (26.1) | 6 (10.3) | 0.013 |
| P value associated with the age and clinical pregnancy rate in each prognostic categorya | 0.031 | 0.041 | 0.007 | |
| P value associated with the age and twin pregnancy rate in each prognostic categorya | 0.256 | 0.076 | 0.708 | |
| P value associated with the age and live birth rate in each prognostic categorya | 0.025 | 0.019 | 0.007 |
Notes:
a
P-value for global comparison between the three groups.
b
Significant comparison between women with favorable and average prognosis.
c
Significant comparison between women with average and poor prognosis.
d
Significant comparison between women with favorable and poor prognosis.
e
Significant comparison in clinical pregnancy rate between women aged 35–37 years and >40 years.
f
Significant comparison in clinical pregnancy rate between women aged 38–40 years and >40 years.
g
Significant comparison in live birth rate between women aged 35–37 years and >40 years.
h
Significant comparison in live birth rate between women aged 38–40 years and >40 years.
i
Significant comparison in live birth rate between women aged 35–37 years and 38–40 years.