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. 2019 Dec 20;11:357. doi: 10.3389/fnagi.2019.00357

Figure 3.

Figure 3

Higher radiation dose leads to autophagy as delayed effects. Brain from naive and animals treated with formulation buffer and BBT-059 were collected at 6 and 12 months post-TBI. The figure shows the representative images of Bcl2 immunohistochemistry (IHC) in brains at 6 and 12 months from naive, 10 Gy irradiated pre-treated with formulation buffer (FB 10 Gy), 10.5, 11.5, and 12 Gy irradiated and pre-treated with BBT-059. At 6 months post-TBI we did not observe any difference between different groups for Bcl2 expression, however, after 12 months post-TBI, a lower expression was observed in the group administered BBT-059 24 h prior to TBI at 11.5 Gy compared to all other groups.