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. 2019 Dec 20;10:1420. doi: 10.3389/fphar.2019.01420

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Copyright © 2019 Coppini, Santini, Palandri, Sartiani, Cerbai and Raimondi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Direct anticoagulants may be thought as indirect PAR inhibitors. Direct anticoagulants including low molecular weight heparins and novel oral anticoagulants (NOAC) have different pharmacokinetic features including the volume of distribution and oral availability but share their ability to inhibit FII and FXa activity. Irrespective of their mechanism of coagulation factors inhibition, direct anticoagulants mimic serpin activity. This effect in turn reduces the possibility that coagulation factors may activate PAR and generate a pro-fibrotic cascade. Figure created using Servier medical art templates.