Figure 4.

Pharmacological strategies to control hyperacoagulability and heart inflammation. Hypercoagulability generates and sustains vascular inflammation and permeability, a condition allowing the chemotaxis of inflammatory cells to neighbor tissues. Activated Inflammatory cells secrete, among the many signals, serine proteases, and disseminate inflammation in the invaded tissue. The control of serine protease activity may be achieved pharmacologically directly and indirectly by using drugs already in use or by promising novel drugs with proved effectiveness in preclinical investigations. Figure created using Servier medical art templates.