Skip to main content
. Author manuscript; available in PMC: 2020 Jan 9.
Published in final edited form as: Lancet. 2019 Sep 15;394(10205):1274–1285. doi: 10.1016/S0140-6736(19)31334-0

Table 1:

Summary of 1-year and 5-year metabolic outcomes after islet transplantation since 2004

1 year 5 years
Median (IQR) Minimum-maximum Number of study arms (patients) Median (IQR) Minimum-maximum Number of study arms (patients)
Transplant function
ITA recipients 93% (75–100) 50–100% 22 (254) 81 (78–100) 74–100% 6 (34)
IAK or SIK recipients 93% (88–100) 86–100% 5 (52) 80 (74–85) 74–85% 2 (24)
Insulin independence
ITA recipients 67% (50–82) 38–100% 23 (170) 40 (14–50) 8–100% 7 (20)
IAK or SIK recipients 51% (28–74) 20–83% 6 (21) 32 (9–54) 9–54% 3 (7)
HbA1c <7% (53 mmol/mol) and no SHEs
ITA recipients 82% (69–94) 40–100% 9 (121) 54 (50–90) 50–100% 4 (13)
IAK or SIK recipients 86% (80–86) 80–86% 3 (18) 59 (58–60) 58–60% 2 (7)

Data from 455 patients, enrolled in 22 studies (a total of 29 experimental arms), were reviewed.1116,25,3347 ITA=islet transplantation alone. IAK=islet-after-kidney transplantation. SIK=simultaneous islet and kidney transplantation. HbA1c=glycated haemoglobin. SHEs=serious hypoglycaemia events.